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According to Irish health data: Approximately 60% of adults in Ireland are overweight or obese Around 1 in 4 adults meet the criteria for obesity Childhood overweight and obesity rates remain a significant concern Rates continue to trend upward over time Obesity is now one of the leading modifiable risk factors contributing to: Type 2 diabetes Hypertension Cardiovascular disease Stroke Certain cancers Osteoarthritis Fatty liver disease From a healthcare system perspective, obesity contributes significantly to long-term healthcare expenditure
In the rodent high fat fed male mice model, administration of semaglutide at the dose of 2800 g/kg/day resulted in a significant weight loss attributed to a decreased food intake [70]
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